Thanks to Semaphore (creator of tiny umbrella) for this information:
It seems that Apple has decided to put a baseband requirement on iOS. So at this point, if you are using Saurik’s server or tiny umbrella and trying to restore 4.2.1 on an iPhone 4, you will end up in recovery mode and tiny umbrella will not be able to pull you out of recovery. In this case, you will have to restore 4.1 again or you will have to restore 4.2.1 stock and be tether jailbroken. (Of course, I recommend 4.1 and not bothering with 4.2.1 at all). If you are an unlocker, this is a no brainer. Do not update to 4.2.1 even to test it at this point.